WFDC2 and ovarian carcinoma: Several other proteins that have been proposed as potential biomarkers for ovarian cancer were identified in the extracellular compartment of cells analyzed in this study, including WFDC2 (HE4) and MUC16 (mucin 16, CA125), a membrane glycoprotein that was significantly enriched in conditioned media from CaOV3, OVCAR3 and ascites cancer cells and which is used as a marker of ovarian cancer [36].