MYCN and neuroblastoma: Analyses of recurrent patterns of somatically acquired DNA copy number alterations resulted in the delineation of three major genetic subgroups with predictive tumour behaviour (subtype 1, 2A and 2B), of which subtype 2A NB represents an aggressive subgroup of metastatic NB [5,6] characterised by loss of 11q, gain of 17q and a normal MYCN copy number status [6].