ERBB2 and cancer: Since genetic activation of therapy targets such as ABL, C-KIT, Her2/neu, and EGFR has been successfully demonstrated to be essential for treatment response [36], our finding of 5p gene targets such as RNASEN, SKP2, and OSMR emphasize the need for functional analysis and dissecting signaling cascades involving these genes in ultimately obtaining therapeutic targets needed for cure and prevention of this devastating cancer.