Considering that none of the previously reported ocular-specific autoantigens in endogenous uveits (such as S-antigen, rhodopsin [38], and recoverin [39]) were detected as candidate retinal autoantigens in the present study, ubiquitously expressed proteins appear to be more immunogenic among antigens exposed to immune system secondarily under tissue-destructive severe uveitis. This evidence concerns the gene RCVRN and uveitis.