α3(IV)NC1 binds to cell surface integrins and inhibits hypoxia induced tumor angiogenesis by (1) inhibiting NFκB activation, leading to inhibition of COX-2 expression, which in turn results in (2) down regulation of hypoxia induced VEGF/bFGF expression in addition to inhibition of cap dependent translation (Table I). Here, VEGFA is linked to neoplasm.