Furthermore, inhibition of cell migration was reported in melanoma and fibrosarcoma cells using native type IV collagen or 185–205 peptide, with a decrease in expression of membrane-bound metalloproteinase (MT1-MMP) and β3 integrin subunit with a decrease in the levels of activated membrane-bound matrix metalloproteinase-2 (MMP-2) (51). Here, MMP2 is linked to melanoma.