PPARδ knockout mice exhibited significantimpaired angiogenesis and tumor growth after these mice were injected s.c. withmouse Lewis lung carcinoma and melanoma cells [79].In a mouse mammary tumor model, treatment with the PPARδ agonist (GW501516) accelerated tumor formation, while a PPARγ agonist (GW7845) delayed tumor growth [80]. The gene discussed is PPARD; the disease is melanoma.