PPARD and neoplasm: Indeed,conflicting results in the context of embryonic lethality have also beenobserved from these two PPARδ mutant mouse strains [74, 75].To further clarify the role of PPARδ in colorectal tumorigenesis, it isimportant to investigate the role of PPARδ in animal models that are dependent onactivation of other oncogenes or disruption of other tumor suppressors toverify our conclusions that activation of PPARδ is proneoplastic.