Concurrence of COX-2 induction with 15LOX-1 downregulationwas found in 6% adenomas, in 33% adenoma components, and 71% carcinomacomponents of carcinoma-in-adenomalesions (all mucosal cancer), in 89% cases innonmetastatic serosa-invading carcinomas, and in 100% cases of nodalmetastasized carcinomas. The gene discussed is PTGS2; the disease is adenoma.