15LOX-1 mRNA was found in 96% ofadenomas, 43% of adenoma in carcinoma-in-adenoma lesions, and 10% of carcinomain carcinoma-in-adenoma lesions, but not in advanced carcinoma (P < .0001).In contrast, COX-2 production was found in 11% of adenomas, 52% of adenoma incarcinoma-in-adenoma lesions, 71% of carcinoma in carcinoma-in-adenoma lesions,and 92% of advanced carcinoma (P < .0001). The gene discussed is ALOX15; the disease is carcinoma.