This was evident by the morphology of C6 and Colo 320 cells (Fig. 3), paxillin staining of U87 glioma (Fig. 2) and Colo 320 cells (Fig. 3B), and phalloidin and vinculin staining of CHO and human skin fibroblasts plated on the 110 kDa fibronectin-like substrate (Fig. 4), indicating that syndecan clustering by the KKDC peptide is translated biochemically to cellular response. This evidence concerns the gene VCL and central nervous system cancer.