TNFRSF1A and infection: Lastly, the infection studies in double TNFtm/tm× TNFR1 or R2−/− transgenic mice rescued protection in TNFtm/tm × TNFR2−/− mice and comparable protection in TNFtm/tm × TNFR1−/− mice as in TNFtm/tm mice suggest that membrane signalling though TNFR2 likely provides host protection.