This hypothesis is further corroborated by increased mycobacterial loads in the lung of TNFtm/tm × TNFR2 KO at 6 weeks post-infection, a time point when all TNF−/− had succumbed, essentially doubled as compared to TNFtm/tm or TNFtm/tm × TNFR1 KO mice (Fig. 11b). This evidence concerns the gene TNFRSF1A and infection.