Such stroma immunoreactivity, that corresponds to a true induction of syndecan-1 synthesis by reactive stromal cells and not simply to the fixation of shedded syndecan-1 to stromal cells (Mennerich et al, 2004), has been initially described in invasive breast carcinomas by Stanley et al, (1999) and confirmed by others (Wiksten et al, 2001; Mennerich et al, 2004). Here, SDC1 is linked to invasive breast carcinoma.