Many variants located in tamdem on 1q32-q22 including those in complement Factor H (CFH), complement factor H-related 4 (CFHR4), complement factor H-related 2 (CFHR2), complement factor H-related 5 (CFHR5), coagulation factor 13 subunit B (F13B), abnormal spindle-like microcephaly associated (ASPM) and zinc finger and BTB domain containing 41 homolog (ZBTB41) were significantly associated with AMD risk (Table 1). The gene discussed is CFHR4; the disease is age-related macular degeneration.