Likewise, in ER/PR positive MCF-7 breast cancer cells, P and MPA (both 100 nM) also provoked the rapid actin reorganization in the absence or presence of E2 (10 nM), which were indicated by the translocation of actin towards cell membrane and by the obvious formation of lamellipodia (Fig. 3, Table 1). This evidence concerns the gene PGR and breast carcinoma.