CSF3 and myelodysplastic syndrome: In a phase 2 study that examined darbepoetin alfa administered 300 μg/week with or without G-CSF, 55% of low-risk MDS patients treated with darbepoetin alfa alone achieved a major erythroid response; additional responses were obtained in patients who had been unresponsive to darbepoetin alfa as a single agent when G-CSF was administered concomitantly with darbepoetin alfa (Mannone et al, 2006).