LRRK2 and multiple system atrophy: This prevalence is similar to those for other neurological disorders, such as multiple system atrophy (4 per 100 000), progressive supranuclear palsy (6 per 100 000), motor neuron disease (6 per 100 000), and common single-gene disorders, such as Huntington's disease (2 per 100 000) and haemophilia A (5 per 100 000).20, 21, 22, 23 Moreover, 3 cases per 100 000 is an underestimate of the overall prevalence of mutations in LRRK2 because it does not include mutations other than LRRK2 Gly2019Ser or the higher frequency of LRRK2 Gly2019Ser in particular populations (table 1).