Indeed, oncogenic fusion proteins resulting form chromosomal translocations associated to acute myeloid leukemias (i.e. PML/RAR, AML1/ETO), exert their oncogenic effect by an aberrant recruitment of repressor complexes, containing DNMT and HDAC activities, on genes that are relevant for hematopoietic differentiation [31]. Here, DNMT1 is linked to acute myeloid leukemia.