The authors expressed doubt that the high incidence of kidney disease in the largest of the families (present in 13 of 30 individuals, reported previously in [30]) could be related to the familial LMX1B genotype, inasmuch as the family contained affected individuals with no evidence of kidney disease, individuals with mild proteinuria alone and individuals whose condition had progressed to kidney failure. This evidence concerns the gene LMX1B and kidney failure.