The SAM-identified gene set spanned diverse biological processes, and included known cancer genes like FGF1 and EVI1. Gene Set Enrichment Analysis (GSEA) [23] confirmed an enrichment of putative upstream GATA factor binding sites among the genes whose expression correlated with elevated GATA6 levels (P = 0.004) (Figure 4B). This evidence concerns the gene FGF1 and cancer.