When the patients with GIinvolvement were compared with patients without the affliction, we found nodifference in the distribution of MCP-1 −2518 SNP (P > .05, Table 3).Furthermore, the allele, genotype, and phenotype frequencies in patients withlimited SSc were similar to those observed in diffuse form of SSc (Table 3). The gene discussed is CCL2; the disease is systemic sclerosis.