PPARA and cancer: Moreover, these reports also suggest thepossibility that targeting PPARs might be a critical strategy for inhibitingthe development and growth of cancers.Indeed, numerous in vivo and in vitro studies have demonstrated thatPPAR agonists, especially, PPARγligands can inhibit cell growth, cause apoptosis, and thus exert antitumoreffects in various types of human malignancies [4–6].Based on the antigrowth and prodifferentiation action of PPARs, severalclinical studies have been conducted using the PPAR ligands in humancancers.