Eventhough significant progress has been made, the mechanism by which NO-ASA exertsits chemopreventive effect against colon cancer is still not completelyunderstood [2].Our data indicate that NO-ASA could exert its colon chemopreventiveeffect, at least in part, by modulating PPARδ function [7]. The gene discussed is PPARD; the disease is malignant colon neoplasm.