PPARG and neoplasm: In addition,since many of the existing studies have demonstrated that the proapoptotic andantiproliferative effects of PPARγ ligands are independent of the receptor;additional studies are required to elucidate PPARγ-dependent from independent events byusing tissue specific knockouts, siRNA approaches, and overexpression studies.Understanding the mechanisms of action of these agents has become a priority todevelop drugs that have beneficial effects on tumor suppression without havingmajor side effects.