Furthermore, a fusionprotein derived from the paired box gene 8 (PAX8) and PPARγ genes (PPARγ-PAX-8) was detected in thyroid cancers,which causes PPARγ not only to be functionally inactivebut also to function as a dominantnegative form of PPARγ [28, 131]. The gene discussed is PAX8; the disease is thyroid cancer.