CDDO also negativelyaffected the levels of an endogenous caspase-8 inhibitor, c-FLIP (caspase-8homolog Fas-ligand interleukin-1-converting enzyme (FLICE)-inhibitory protein).However, downregulation of c-FLIP expression was not the sole pathway activatedby CDDO, as c-FLIP antisense oligonucleotides did not induce CLL apoptosis [199]. This evidence concerns the gene CFLAR and B-cell chronic lymphocytic leukemia.