TZD enhancestumor formation in the APCmin model [141] and the bigenic miceoverexpressing PPARγ in the MMTV-neu breast cancer modelhave more, highly differentiated tumors [157].In retrospect, these high-profile studies perhaps reveal important facts of thedominant relationship between Wnt signaling over PPARγ in the mouse. This evidence concerns the gene PPARG and breast cancer.