The long-term effect of TZD onliposarcomas requires further study; nevertheless, these pioneer studiesspurred the examination of the effect of TZDs on a number of cancers both in vitro and in vivo in colon, breast, prostate,myeloid leukemia, neuroblastoma, glioblastoma, lymphoma, lung, cervical,bladder, head and neck, esophageal, gastric, pancreatic, and choriocarcinomacancers [21, 81, 110–140].The multiple findings from studies illustrate the promise and failings oftargeted therapies toward PPARγ to restore mitotic restraint and inducedifferentiation. The gene discussed is PPARG; the disease is cancer.