In rodent models, the PPARγ agonists block N-nitroso-N-methylurea-inducedbreast cancer in Sprague-Dawley rats [155]and DMBA-induced breast cancer in mice [114].Similarly, Pparγ+/− mice have a greatersusceptibility to develop breast and ovarian cancers after their exposure to7,12-dimethylbenz(a)anthracene [156]. Here, PPARG is linked to ovarian carcinoma.