PPARG and malignant colon neoplasm: Surprisingly, administration of TZD to APCmin mice resulted in increased frequency of colon cancers compared to controlanimals [141].Subsequently, however, generation of the intestinal specific Pparγ−/− and APCmin bigenic mousedemonstrated an unequivocal effect of Pparγto suppress tumor formation and suggests that significant off-target effects ofTZD occur in mice, especially in the APCmin mouse colon cancer model[142].