Of interest too is the observation is that ABCA4 is selectively expressed in the choroid plexus throughout development [39], [40], suggesting a possible role for ABCA4 in determining pathology in brain in addition to eye, that would be consistent with the association observed with hydrocephalus, in particular when examining associations between mother's genotype and clinical outcome in the child for the European cohort. The gene discussed is ABCA4; the disease is Hydrocephalus.