Another SNP, rs3779748 in EYA1, was significantly associated with CKD at study visit 1, a kidney trait different from but related to the ones significantly associated in FHS, eGFR and cystatin C. Our findings may provide guidance for investigators wishing to further replicate the associations from this GWAS of renal traits, as well as present considerations and mechanisms of SNP selection for replication studies. The gene discussed is CST3; the disease is chronic kidney disease.