Interestingly, Arteaga and Baselga [14] have noticed that EGFR-positive colon carcinomas with simultaneous expression of pEGFR, coexpressed the EGFR ligand transforming growth factor-α and markers of tumour proliferation, which is in contrast to EGFR-positive/pEGFR-negative carcinomas. Here, EGFR is linked to carcinoma.