These mostcommonly included MDM2 DNA amplification, MDM2 mRNA over-expression and MDM2 oncoprotein over-expression.However, some soft tissue sarcoma patient specimens had no evidence of MDM2 mRNA over-expression yet hadMDM2 oncoprotein over-production in the tumor relative to autologous normal tissue, implying possible post-transcriptionalregulation. This evidence concerns the gene MDM2 and neoplasm.