Since then, the expansion of angiogenesis research has resulted in the identification of various pro- and anti-angiogenic factors, such as FGF, VEGF, angiopoietin, endostatin, vasostatin, and neuronal cell axon guidance molecules [2,7-9] and the development of several anti-tumor angiogenesis medicines that have recently proven efficacious in the clinic [1,2,7,10,11]. This evidence concerns the gene VEGFA and neoplasm.