We were specifically interested in documenting the measured changes in insulin resistance, endogenous beta-cell processing/secretion of insulin and platelet cation concentration and membrane ATPase activity in a cohort of thiazide-treated hypertensive patients with prospectively defined normal glucose tolerance, impaired glucose tolerance and hitherto undiagnosed and untreated type 2 diabetes mellitus. The gene discussed is INS; the disease is Impaired glucose tolerance.