BCL2 and Kaposi's sarcoma: HHV-8 ORF16 encodes the so-called Kaposi sarcoma–associated Bcl-2 (KSBcl-2), a polypeptide of 175 residues that shares limited (15%–20%) overall sequence identity with other Bcl-2 homologs (including Bcl-2, Bcl-XL, Bax, Bak, and BHRF1) [71].