At the common infection dose of 1 × 105 bacteria for cows 1419, 1490 and 1592, there was 5.2, 36.5 and 49.1 fold up-regulation of S100A12 expression and 11.1, 9.9 and 19 fold up-regulation of PTX3 expression, compared to the intra-animal controls, respectively (all P < 0.01) (Fig. 1(c)). The gene discussed is PTX3; the disease is infection.