Tumor markers, including carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), squamous cell carcinoma (SCC) antigen, cytokeratin 19 (CK19), vascular endothelial growth factor-C (VEGF-C), heterogeneous ribonuclear proteins A2/B1 (hnRNP A2/B1), muc1, BJ-TSA-9, KS1/4 and lung-specific X protein (LunX), have been investigated for their putative diagnostic and prognostic value for lung cancer [1-7]. Here, ENO2 is linked to neoplasm.