BRCA1 and ovarian cancer: There was no significant effect of ovarian cancer cluster regions (OCCR, nucleotides 2401–4190 BRCA1 and nucleotides 3035–6629 in BRCA2) for either gene with lifetime ovarian cancer risks (to 80 years) of 65% for 573 BRCA1 carriers outside the OCCR and 70% for 266 women with mutations within the OCCR (p = 0.18).