Representative micrographs from the cerebral cortex of AD mice were shown in Fig. 1 A through D. Morphometric analysis of the CD11b immunostaining revealed that the cerebral cortex of TLR4m AD mice (1.10 ± 0.18%) had greater microglial immunoreactivity than TLR4w AD mice (0.45 ± 0.10%, P = 0.021) (Fig. 1E). Here, ITGAM is linked to Alzheimer disease.