Furthermore, Aβ upregulates expression of β-1,4-mannosyl-glycoprotein 4-β-N-acetylglucosaminyltransferase (MGAT3) and TLRs in mononuclear cells from normal subjects, whereas these genes were down-regulated in cells from AD patients [22], suggesting immune defects in AD patients. This evidence concerns the gene MGAT3 and Alzheimer disease.