The average relative cost-effectiveness of cardiac imaging compared with the PhSE equal to 1 (as a cost comparator), the relative cost of ex-Echo is 1.5×, of a ex-SPECT-Tc is 2,9× and 3.1× including cost for extra risk of cancer, of a ex-ECG is 3.5×, of cTnI is ×3.8, of cTnT is ×3.9 and of a CA is 56× and 56,3× including cost for extra risk of cancer (Figure 4). Here, TNNI3 is linked to cancer.