Recently, CD133 (prominin-1: PROM1), a 5-transmembrane glycoprotein, was identified as an important marker representing a subset population of cancer stem-like cells (CSCs) in leukemia, retinoblastoma, colon cancer, prostate carcinoma, brain tumor, and hepatoma [19]–[23]. This evidence concerns the gene PROM1 and colonic neoplasm.