PPARG and retinal disorder: Therefore, asdual ARB/SPPARγM ligands, telmisartan and irbesartan have importantdifferential effects on PPARγ-dependent regulation of gene transcription,without the limitations of fluid retention and weight gain, providing improvedtherapeutic efficacy by combining potent antihypertensive, antidysmetabolic,anti-inflammatory, and antiproliferative actions in the treatment of theproliferative retinopathies.