While PPARγ has been shown to upregulate E-cadherin in NSCLC, there are nostudies demonstrating direct binding of PPARγ to the E-cadherin promoter.A family of transcription factors have been identified which act assuppressors of E-cadherin expression.Members of this family include Snail1, Snail2 (Slug), ZEB1, and Twist [58, 59] are potent inducers of EMT. This evidence concerns the gene SNAI2 and non-small cell lung carcinoma.