More recently, five published clinical trials: Early Goal-Directed Therapy [2], Recombinant Human Activated Protein C [3], Low-Dose Steroid [4], Low-Tidal Volume-ARDS Network [5], and Intensive Insulin Therapy [6] demonstrated positive outcome results and brought the prospect of improving the survival of patients with severe sepsis. The gene discussed is INS; the disease is Sepsis.