We previously found that bee venom and its major component, melittin inhibits inflammatory stimuli such as LPS, TNF-α, and SNP-induced NF-κB activation by preventing p50 translocation via an interaction between melittin and sulfhydryl group of p50 and/or IKKα and IKKβ, and that these inhibit inflammatory reaction in the development of rheumatoid arthritis [4,5]. This evidence concerns the gene NFKB1 and rheumatoid arthritis.