INS and cardiovascular disorder: This biphasic insulin analogue consists of 30% free and 70% protamine-bound insulin aspart, and is expected with its twice-daily pre-meal injections to improve patient compliance to insulin injection therapy as well as the quality of life (QOL) of patients given the treatment, while at the same time improving postprandial hyperglycemia better than conventional mixed preparations, thus potentially reducing the risk for cardiovascular disease.