MGMT and central nervous system cancer: Several teams have reported this increased chemosensitivity for various types of gliomas (Balana et al, 2003; Paz et al, 2004; Hegi et al, 2005; Watanabe et al, 2005; Herrlinger et al, 2006; Chinot et al, 2007) and MGMT status, either methylation or level of expression, has become a predictive marker of chemosensitivity.