EGFR and brain neoplasm: EGFR is the main oncogene identified in brain tumours, but its prognostic value is controversial (Chakravarti et al, 2001; Muracciole et al, 2002; Miracco et al, 2003; Shinojima et al, 2003; Heimberger et al 2005a, 2005b; Kleinschmidt-DeMasters et al, 2005; Lopes-Gines et al, 2005; Quan et al, 2005; Rich et al, 2005), although a fairly strong correlation with OS was observed in the present study.