In the present study, we evaluated by western blot the expression of the SV-1 of GHRH-R and its GHRH ligand in human breast cancer (MDA-MB-468, MDA-MB-435S, T47D), prostate cancer (LNCaP) and non-SCLC (NCI H838) cell lines. The gene discussed is GHRH; the disease is Familial prostate cancer.