GHRH and breast carcinoma: The inhibition of the gene expression for GHRH in T47D breast cancer cell line did not have the potent antiproliferative effect found in the other two breast cancer cell lines (MDA-MB-468 and MDA-MB-435S), possibly because the ligand independent activity of the SV1 continued to enhance the proliferation rate of the T47D cells (Kiaris et al, 2003; Barabutis et al, 2007).