VEGFA and brain neoplasm: Also, in light of our previous studies that showed that anti-VEGF treatment of brain tumours resulted in undetectability using Gd-DTPA MR imaging (due to restoration of the blood–brain barrier (Leenders et al, 2004; Claes et al, 2008)), USPIO imaging may be an attractive avenue to delineate brain tumours and evaluate antiangiogenic therapy.