Inflammatory breast cancer more frequently than NIBC is characterised by an early age at diagnosis, negative hormone receptor status, high nuclear grade, HER2/neu gene amplification and overexpression, and by pronounced neo-angiogenic and invasive features (Turpin et al, 2002; Anderson et al, 2003; Sawaki et al, 2006). The gene discussed is ERBB2; the disease is inflammatory breast carcinoma.