A negative influence of EGFR targeting on angiogenic biochemical mediators has been shown for both mAbs and TKIs; for instance, the tumour labelling in VEGF (vascular endothelial growth factor) and factor VIII was reduced in xenograft models by C225 (Huang and Harari, 2000) as well as by ZD1839 (Tortora et al, 2001). The gene discussed is EGFR; the disease is neoplasm.