CDH1 and cancer: For example, immunohistochemical studies have shown that low expression of E-Cadherin is associated with poor survival in a number of cancers including pancreatic (Shimamura et al, 2003), thyroid (Scheumman et al, 1995), gall bladder (Hirata et al, 2006), breast (Park et al, 2007), lung (Nozawa et al, 2006), hepatic (Wu et al, 2006), endometrial (Scholten et al, 2006), and colon (Pena et al, 2005) cancer.