Despite the known biological properties of B2M, this gene has been inadvertently used as an internal reference control in studies involving IFN signalling (Einav et al, 2005; Tamassia et al, 2007), as well as real-time PCR studies of colon cancer prognosis (Takeuchi et al, 2003). This evidence concerns the gene IFNA1 and malignant colon neoplasm.