ICAM1 and type 1 diabetes mellitus: In order to further evaluate the susceptibility of the ICAM-1 genetic polymorphisms in the development of DN, in the present study, we have focused on genetic association analyses of two common non-synonymous SNPs i.e. rs5498 E469K(A/G) and rs1799969 R241G(G/A) in the ICAM-1 gene by using the well-selected and characterized cohort of T1D patients with and without DN from the Genetics of Kidneys in Diabetes (GoKinD) study [20].