The data hereinhighlight further critical differences between the TPα and TPβ receptor isoformsin terms of their regulation of Rho signaling that are likely to bephysiologically relevant in human tissues such as SM and suggest that selectivetargeting and impairment of TPα-mediated signaling may offer a usefultherapeutic approach in the treatment of certain vascular diseases such assystemic- and pulmonary-hypertension in which both TXA2 andRhoA dysfunction has been implicated [2,48,49]. Here, RHO is linked to pulmonary hypertension.