BRCA1 and ovarian carcinoma: The index cases of 61 families included in this study were analyzed for rearrangements in the three genes by MLPA, and in one family we identified a large deletion in BRCA1. The observed deletion removes most of the gene including the promoter [21], thereby preventing the transcription of BRCA1. The mutation positive patient displayed a family history of ovarian cancer, which has been shown to increase the likelihood of finding a BRCA1 mutation in a family [22].