In a recent study, Chen et al. report a close correlation of tissue polypeptide specific antigen (TPS), neuron-specific enolase (NSE), carcinoembryonic antigen (CEA) and beta(2)-microglobulin (beta(2)-mG) in serum with lung cancer, histological grades and lymphoid nodule metastasis [14]. This evidence concerns the gene ENO2 and lung carcinoma.